中文摘要：

以6-氯邻氨基苯甲酸为起始原料，与醋酐酰化关环制得6-氯-2-甲基嗯嗪-4-酮（1）；1在80％水合肼中回流反应制得6-氯-2-甲基-3-氨基-4（3H）-喹唑啉酮（2）；2与羟基芳醛反应合成了4种新型的6-氯4（3H）-喹唑啉酮类Schiff碱（4a-4d），其结构经。HNMR，13C NMR，IR和元素分析表征。采用琼脂扩散法研究了4a～4d对金黄色葡萄球菌（A）、大肠杆菌（B）和枯草杆菌（C）的抑制活性。结果表明：用药浓度为300mg·mL-1时，4a-4d对A～C均有一定的抑制活性，其中6-氯-2-甲基-3-（5-甲基-2-羟基苯亚甲氨基）-4（3H）-喹唑啉酮（4c）抑菌活性最强，对A～C的抑菌圈直径分别为8．8mm，11．9mm和9．6mm。

英文摘要：

6-Chlor-2-methyl-3,1-benzoxazin-4-one （1） was prepared by acylated cyclization of 6- chlor-anthranilic acid with acetic oxide. 3-Amino-6-chlor-2-methyl-4（3H）-quinazolinone （2） was obtained by refluxing reaction of 1 in 80% N2 H4 · H2 O. Four novel 6-chlor-4 （3H） -quinazolinone Schiff bases（4a - 4d） were synthesized by the reaction of 2 with hydroxyl arylamine. The structures were characterized by 1H NMR, 13C NMR, IR and elementary analysis. The preliminary antibacterial activities of 4a - 4d against Staphylococcus aureus （A）, Escherichia coli （B） and Bacillus subtilis （C） were investigated by agar diffusion method. The results showed that 4a - 4d exhibited certain antibacterial activities with drug concentration of 300 mg · mL - 1 and 6-chlor-2-methyl-3- [ （ 5-methyl-2-hydroxyphenyl） methylene amimo ] -4 （3H） -quinazolinone （4c） was the best, which possessed 8.8 mm, 11.9 mm and 9.6 mm inbibition zone diameters against A - C, respectively.