中文摘要：

为探讨内皮型一氧化氮合酶（eNOS）基因27bp VNTR多态性与新疆汉族原发性高血压（EH）的相关性。采取整群随机抽样的方法,选取新疆沙湾县汉族346名EH患者（EH组）与385名正常对照者（NT组）为研究对象,进行流行病学调查和临床检查,并采集血样。采用荧光标记扩增产物长度多态分析方法检测eNOS基因27bp VN-TR多态性。结果显示：eNOS基因27bp VNTR基因型bb.aa.ab.bc在EH组及NT组中的分布频率分别为278（80.3%）、3（0.9%）、65（18.8%）、0（0%）和306（79.5%）、4（1.0%）、74（19.2%）、1（0.3%）。等位基因b、a、c在EH组和NT组中分布频率分别为621（89.7%）、71（10.3%）、0（0%）和687（89.2%）、82（10.6%）、1（0.2%）,EH组和NT组基因型和等位基因分布频率无显著性差异（P〉0.05）。由此可知,eNOS基因27bp VNTR多态性可能与新疆汉族原发性高血压不相关。

英文摘要：

We investigate the association of the 27bp VNTR polymorphism of the endothelial nitric oxide synthase（eNOS） gene with essential hypertension（EH） in the Han people in Xinjiang.Based on the case-control study,we selected 346 patients with essential hypertension（EH group）and 385 healthy people（NT group） in the Han people from the Boertonggu countryside of Shawan region in the Xinjiang Uygur Autonomous.Region of China by random cluster sampling.After questionnaire and physical examination,we collected blood samples,The polymorphisms of eNOS gene in the study groups were detected with fluorescent amplified product length polymorphism analysis system.Frequency and allele frequency were calculated and compared.The frequencies of bb.aa.ab.bc genotypes of eNOS gene were 278（80.3%）,3（0.9%）,65（18.8%）,0（0%）in EH group respectively and 306（79.5%）,4（1.0%）,74（19.2%）,1（0.3%） in NT group respectively.The frequencies of b,a and c were 621（89.7%）,71（10.3%）,0（0%） in EH group and 687（89.2%）,82（10.6%）,1（0.2%） in NT group.The result of related analysis in groups indicated that no significant difference was observed in the comparison of either genotype frequencies or allele distribution between hypertension and control groups（P〈0.05）.The polymorphism of eNOS gene 27bp VNTR may not be associated with essential hypertension in the Han people in Xinjiang.