目的探讨心外膜脂肪组织(EAT)与颈总动脉内中膜厚度(CIMT)、冠心病的相关性,进一步分析EAT预测冠心病的意义。方法入选确诊冠心病需行冠脉造影住院患者160例(其中非冠心病86例,冠心病74例),入院后10d内彩超检测EAT厚度、CIMT厚度,分析EAT厚度与CIMT厚度、冠心病的相关性。结果相关性分析显示,EAT厚度与CIMT有较好的相关性(r=0.79,P〈0.001);冠心病组EAT、CIMT较非冠心病组明显高[(8.65±1.45)vs(6.30±1.53)mm;(1.17±0.21)VS(0.83±0.19)mm;均P〈0.01)];CIMT≥0.92mm预测冠一tL,病的敏感度、特异度、Youden指数分别为0.81、0.78、0.59,EAT≥7.24mm预测冠心病的敏感度、特异度分别为0.84、0.80、0.64。结论超声检测EAT和CIMT可作为冠心病的预测指标。‘
Objective To explore the correlation among epicardial adipose tissue (EAT) , carotid artery intima medial thickeness (CIMT) and coronary heart disease(CAD) , further analyze the significance of EAT to predict CAD. Methods 160 hospitalized patients with CAD underwent coronary angiography were consecutive selected, including 86 cases with non-CAD, 74 cases with CAD, within admis- sion 10 d, the EAT and CIMT thicknesses were measured by color Doppler ultrasound. Results Correlation analysis showed,EAT thickness had good eorrelation with CIMT ( r = O. 79 ;P 〈 0. 001 ). Compared with those of non-CAD group, EAT, CIMT of CAD group were significant- ly higher( (8.65 ± 1.45) vs. (6. 30 ± 1.53) mm; ( 1.17 ±0. 21 ) vs. (0. 83 ±0. 19) ram, P 〈0. 0017. For patients with coronary artery stenosis 〉 50%, the sensitivity, specificity and Youden index of CIMT ≥ 0. 92 mm were 0. 81,0. 78,0. 59, respectively; the sensitivity, spe- cificity and Youden index of EAT ≥ 7.24 mm were 0. 84,0. 80,0, 64, respectively. Conclusions Color Doppler detection of EAT and CI MT may have the Potential to be a oredictor of risk factors for CAD and arteriosclerosis.