中文摘要：

EH是一类由多基因和环境因素共同影响导致的复杂遗传性疾病,遗传因素对血压变化的影响占30%-50%。自1992年Jeune Maitre等首次报道血管紧张素原（angiotensinogen,AGT）基因多态性与EH相关,开创了EH基因多态性关联研究的先列。在众多的EH候选基因中,围绕肾素-血管紧张素-醛固酮系统、交感神经系统、下丘脑-垂体轴、内皮素、利钠肽、激肽释放酶-激肽系统等至少150种EH候选基因进行了广泛研究[1]。在众多候选基因中内皮型一氧化氮合酶（endothelial nitric oxide synthase,eNOS）基因由于对血压调节的重要作用而倍受重视。现就eNOS基因多态性与EH的相关性做一综述。

英文摘要：

EH was complex genetic diseases, which was the result caused by the affect of a class of multiple genes and environmental factors. The impact of changes in blood pressure accounted for 30% -50% ^[2]. Since 1992, the first report by Jeune Maitre reported that angiotensinogen （angiotensinogen, AGT） gene polymorphisms was realted EH, gene creating a gene polymorphism EH associated studies which set a precedent, Among the many candidate genes for EH, centering on the renin - angiotensin - aldosterone system, sympathetic nervous system, hypothalamus - pituitary axis, endothelin, natriuretic peptide, kallikrein - kinin system at least 150 candidates EH genes have been extensively studied [3]. Among the many candidate genes endothelial nitric oxide synthase （endothelial nitric oxide synthase, eNOS） gene was increased attention due to the to the important role devoted to the regulation of blood pressure. The paper was a summary for the relevance of ENOS polymorphisms and EH.