中文摘要：

合成了双（2-取代-3-羟基-4-吡喃酮）合铜（Ⅱ）配合物,采用元素分析、质谱、红外光谱、电子光谱、电子自旋共振谱表征了它们为平面正方型配合物,中心离子和配体的物质的量比为1：2.在STZ-糖尿病小鼠模型上,其中双（2-乙基-3-羟基-4-吡喃酮）合铜（Ⅱ）在10mg/kg的剂量下灌胃给药,能增加血清胰岛素的合成和分泌、降低糖尿病小鼠的血糖水平,显示出良好的抗糖尿病的作用.该配合物毒性低,对正常小鼠灌胃给药的半数致死量LD50是855.9mg/kg.

英文摘要：

Copper（Ⅱ） bis（2-substituted 3-hydroxy-4-pyronate）, where the substituent is CH3/C2H5/CH2OH, was synthesized by the reaction between CuCl2 and sodium 2-substituted 3-hydroxy-4-pyronate in aqueous solution, followed by recrystaUizaton in water. By using elemental analysis, IR, UV, MS and EPR spectra, their chemical structures were determined to be planar square complexes with 1 ： 2 molar ratio of Cu to the pyronate in a molecule. The complexes were submitted to the test of preliminary toxicity and anti-hyperglycemic effect on STZ-diabetic mice. The results show that one of the complexes, copper（H） bis（2-ethyl-3-hydroxy-4-pyronate）, increased the synthesis and release of the serum insulin, and lowered the blood glucose level in mice at the dose of 10 mg/kg, exhibiting good anti-hyperglycemic activity. The complex was also safe with LD50 of 855.9 mg/kg in healthy mice.