中文摘要：

目的设计合成双（a-呋喃甲酸）氧钒（VO-FA）的衍生物，并进行降糖活性比较．方法采用元素分析、红外光谱、紫外光谱、质谱和核磁共振氢谱初步确证化合物的结构，并进行降糖作用研究，观察样品灌胃给药对四氧嘧啶性糖尿病小鼠血糖水平的影响．结果合成的2个VO-FA衍生物中，双（5-溴-a-呋喃甲酸）氧钒（VO-FABr）没有降糖作用，双（a-四氢呋喃甲酸）氧钒（VO-HFA）的降糖活性则低于VO-FA，且两者的毒性均大于VO-FA．结论在VO-FA分子的呋喃环上打开环内双键或引入溴均降低其生物学活性，而增加毒性．

英文摘要：

Objective To design and synthesize derivatives of bis （a -furancarboxylato） oxovanadium （IV） （VO -FA）, and to compare their hypoglycemic effects with VO -FA in alloxan -diabetic mice. Methods The chemical structure of the derivatives was determined by elemental analysis, IR, UV, MS and H NMR spectra. The Effects of the derivatives on the blood glucose concentrations were investigated in alloxan - induced diabetic mice. Results During the experiment, his （ a - tetrahydrofurancarboxylato） oxovanadium （Ⅳ） （ VO - HFA） reduced the blood glucose in alloxan - diabetic mice, but was less active than the parent compound VO - FA. Bis （5 - bromo - a - furancarboxylato） oxovanadium （Ⅳ） （ VO - FABr） had no hypoglycemic effect. Both derivatives were more toxic than VO - FA. Conclusion Hydrogen addition of C = C in the ring or introduction of bromine will lower hypoglycemic activity and increase toxicity of the parent compound.