中文摘要：

钒作为人体必需的微量元素，在葡萄糖的代谢过程中起着重要作用。大量的体内外研究表明微量元素钒具有“胰岛素样（insulin-mimics）”作用，研究表明它能增加胰岛素的敏感性，是“胰岛素的促进剂（insulin—enhancing agent）”，可用于治疗和缓解1型和2型糖尿病。然而，无机钒盐（如硫酸氧钒、钒酸钠等）脂溶性小，不易吸收，毒性较大，

英文摘要：

To study insulino-mimetic effects of bis （α-iurancarboxylato） oxovanadium （ Ⅳ） （ BFOV） , a orally active antidiabetic vanadyl complex, on glucose uptake and lipogenesis in isolated rat adipocytes were determined by using 2-deoxy-D-[3H ]-glucose and D-[3H ]-glucose, respectively. Lipolysis was assayed by free fatty acids （FFA） released from isolated rat adipocytes treated with epinephrine. The results showed that BFOV, similar to insulin, concentration-dependently significantly enhanced the uptake of 2-deoxy-D-[ 3H ]-glucose and the transformation from D-[ 3H ]-glucose to lipid in isolated rat adipocytes, with the EC50 values of （0.31 ＋ 0. 08） mmol · L^-1 and （0.49 ＋ 0. 12） mmol· L^-1, respectively. Moreover, BFOV markedly inhibited FFA release from isolated rat adipocytes treated with epinephrine, and the IC50 value was （0. 30 〉 0. 20） mmol · L^-1 BFOV had insulino-mimetic effects such as enhancing glucose uptake and lipogenesis, as well as inhibiting lipolysis.