中文摘要：

目的：研究天山雪莲主要活性成分绿原酸和芦丁的大鼠在体肠吸收动力学。方法：采用单向灌流实验技术，利用HPLC法测定绿原酸和芦丁的量，分别研究药物质量浓度及吸收部位对绿原酸和芦丁吸收的影响。结果：药物质量浓度对绿原酸和芦丁吸收速率常数（Ka）和表观吸收系数（Papp）无显著性影响；绿原酸和芦丁在小肠各段间吸收的Ka和Papp无显著性差异，但与结肠相比吸收明显增大。结论：一定范围的药物浓度对绿原酸和芦丁的Ka和Papp，无显著性影响，其吸收机制为被动扩散。药物在全肠道吸收较好，吸收窗主要在小肠，且小肠内无明显的特定吸收部位。

英文摘要：

OBJECTIVE To study the intestinal absorption behaviors of chlorogenic acid and Rutin in Saussurea involucrate, and provide the scientific basic for the Saussurea inwducrate formulations. METHODS The rat single-pass intestinal perfusion technology and HPLC were used to investigate the concentration of the drugs, and further study the influence of concentration on absorption of chlorogenic acid and Rutin. RESULTS The concentration had no distinctive effect on the Ka and Papp of chlorogenic acid and Rutin; The same results were observed in different segment of small intestine. The absorption in small intestine increased significantly, compared with the colon. CONCLUSION The certain range of drug concentration had no distinctive influence on the Ka and Papp Of Chlorogenic acid and Rutin; the absorption mechanism may be the passive diffusion transport. The drugs had extensive absorption in all small intestine segments; the absorption zone was mostly in the intestine and there is no distinguishable absorption part in the intestine.