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中文摘要：
药物递送系统如能通过光热触控将包裹的药物释放,同时进行癌症成像和治疗,这将是一个新兴的探索焦点。我们合成了一种新型多功能的纳米脂质体药物递送系统,即所述的光热敏感脂质体（PTSL）,它的水溶性层掺杂了阿霉素作为治疗剂,同时它的疏水层包裹了cypate作为诊断剂。我们测试了PTSL的物理性质,稳定性以及脂质体的装载性能,合成的纳米复合材料具有针对性,稳定性和精准性,具有载药量9±1.5%和包封率82.7±2.1%。其Tm值落在43.1℃,提高脂质体的Tm温度达到热敏脂质体的热敏温度,脂质体崩解同时包裹的化疗药物释放。这表明该PTSL可用于肿瘤的诊断和靶向治疗。
英文摘要：
It is an emerging focus to explore a drug delivery system displayed a photothermal release of entrapped drug for simultaneous cancer imaging and therapy.We synthesized a novel multifunctional nano liposome drug delivery system,the photothermal sensitive liposome（PTSL）,with doxorubicin wrapped in the hydropholic layer as the therapeutical agents and cypate dopped in the hydrophobic layer as the diagnostic agents.The physical properties,stabilities and loading properties of the liposomes were tested,the nano composites we synthesized were targeted,stable and delicate,with a drug loading（DL） of 9±1.5% and encapsulation efficiency（EE） of 82.7±2.1%.The Tm value falls on 43.1℃,and it can raise the temperature of liposome to the Tm of thermal sensitive liposome,the liposome cracks and the wrapped chemotherapy drugs release.It indicates that the PTSL is a kind of promising drug delivery system for tumor diagnosis and targeting therapy.
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