中文摘要：

目的：建立欣力胶囊中黄芪甲苷的含量测定方法。方法：采用HPLC-ELSD法测定欣力胶囊中黄芪甲苷的含量，Agilent ZOBAX C18色谱柱（4．6mm×250mm，5μm），流动相为乙腈-水（32：68），流速为1．0mL·min^-1，柱温30℃，ELSD载气流速2．5L·min^-1。结果：黄芪甲苷在2．57～12．85μg范围内有良好的线性关系（r=0．9997），平均回收率（n=6）为98．2％。测定了3个批次欣力胶囊中黄芪甲苷的含量，其含量范围为0．29～0．30mg·粒^-1：该方法准确，重复性好，为欣力胶囊的质量控制提供了一种检测方法。

英文摘要：

Objective：To establish an HPLC-ELSD method for the determination of astragaloside Ⅳ in Xinli cap-sules. Method： HPLC system consisting of an Agilent ZOBAX C18 column （4.6 mm×250 mm,5 μm）and a mixture of acetonitrile -water （32： 68） as the mobile phase was adopted and the flow rate was 1.0 mL·min^-1. The column temperature was set at 30℃. The flow rate of carrier gas was 2.5 L·min^-1.Results： Astragaloside IV showed good linearity （r=0.9997） in the range of 2.57-12.85μg. The average recovery （n=6） was 98.2%. Three batches of Xinli capsules were analyzed, and the content of astragaloside IV ranged from 0. 29 -0. 30 mg per capsule. Conclusion：This method possesses merits of good accuracy and reproducibility. The method can be used for the quality control of Xinli capsules and validate the manufacture technology of Xinli capsules.