中文摘要：

动脉血栓和深静脉血栓等一直是危害人类健康的常见血管性疾病，血栓的存在会对血管壁的壁面剪切力和压力造成巨大影响，而血液动力学的改变也会影响血栓的运动。今通过CFD软件建立简化的冠状动脉血管模型，比较了非牛顿型血液和牛顿型血液的差别，并数值模拟了血管中血液和血栓的两相流动，研究了不同大小和存在形式的血栓随血液流动的规律以及血栓大小、血栓密度、阻塞率及其不同存在形式对血管壁的影响。结果表明，附壁血栓移动很小，游离血栓移动速度随血速的增大而增大；血栓的存在会造成血管壁的壁面剪切力和压力增大，导致损伤血管壁内膜。

英文摘要：

Arterial thrombosis and deep vein thrombosis has been a hazard to human health as a common vascular disease. The presence of thrombus can also cause a serious impact on the wall shear stress and vascular wall pressure, and the change of hemodynamic can also affect the movement of thrombus. In this paper, CFD software was used to establish a simplified model of the coronary artery. The difference between non-Newtonian blood and Newtonian blood were compared, and the two-phase flow of blood and thrombus in blood vessels was simulated to study the law of the flow of different sizes and forms of thrombus as well as the influence of the size, the density of thrombus, the blocking rate and different forms of thrombus on the vascular wall. The result shows that mural thrombus is hard to move, while the velocity of free thrombus increases with the increase of velocity blood; Presence of thrombus in the vessel wall can lead to pressure change and wall shear stress rise, causing damage to the vessel wall intima.