欢迎您！东篱公司
退出
-
申报数据库
-
立项数据库
-
成果数据库
-
项目获奖数据库
中文摘要：
肝细胞癌（HCC）占我国大陆地区恶性肿瘤死亡原因的第二位，主要由乙型肝炎病毒（HBV）慢性感染所致．人类白细胞Ⅱ类抗原遗传多态性与HBV感染的慢性化有关．HBV与免疫系统相互作用导致的非可控性炎症是HBV进化和HCC发生的必要因素．持续的、非充分的抗病毒免疫对HBV变异有选择作用．在炎症促癌过程中病毒和肝细胞基因组均经历了“变异．选择．适应”的进化过程．HBV变异不但能预测HCC的发生，而且具有促癌功能．HBV在肝细胞基因组中整合，尤其是羧基端截短型x基因的整合不但促进HCC的发生和转移，而且抵抗抗病毒治疗．明确HBV致癌机制可为降低和推迟HCC的发生和转移奠定基础．
英文摘要：
Hepatocellular carcinoma （HCC）, the second cause of cancer-related death in mainland China, is mainly caused by chronic hepatitis B virus （HBV） infection. Genetic predisposition of human leukocyte antigen class 1I contributes to the maintenance of chronic HBV infection. Nonresolving inflammation resulted om the interaction of HBV and immune system is essential for the evolution of HBV and subsequent HCC occurrence. Persistent and insufficient antiviral immunity positively selects HBV mutants. During the inflammation-promoting carcinogenesis, genome of both HBV and hepatocyte experiences an evolutionary process of ＂mutation- selection-adaptation＂. HBV mutations not only predict but also promote the occurrence of HCC. The integration of HBV genome, especially in a form of the carboxylic-terminal truncated HBV X protein, not only promotes HCC occurrence and metastasis, but also confers the resistance to antiviral treatments. Understanding the mechanisms by which HBV induces hepatocarcinogenesis will lay the foundations for decreasing and postponing HCC occurrence and metastasis in the HBV-infected subjects.
同期刊论文项目
同项目期刊论文
Downregulation of ATP-Binding Cassette Subfamily C Member 4 Increases Sensitivity to Neoadjuvant Rad
Epidemiological and etiological characteristics of hand, foot, and mouth disease in Ningbo, China, 2
Mother-to-child transmission of hepatitis B virus: evolution of hepatocellular carcinoma-related vir
Association of miRNA-122-binding site polymorphism at the interleukin-1 alpha gene and its interacti
Expression of Orphan Nuclear Receptor NR4A2 in Gastric Cancer Cells Confers Chemoresistance and Pred
Associations of Polymorphisms in DNA Repair Genes and MDR1 Gene with Chemotherapy Response and Survi
D9S168 Microsatellite Alteration Predicts a Poor Prognosis in Patients With Clear Cell Renal Cell Ca
Interaction of signal transducer and activator of transcription 3 polymorphisms with hepatitis B vir
Knowledge Levels and Training Needs of Disaster Medicine among Health Professionals, Medical Student
Human cytidine deaminases facilitate hepatitis B virus evolution and link inflammation and hepatocel
Contribution of a potential functional pre-miR-218 polymorphism and its interaction with hepatitis B
Viral and host inflammation-related factors that can predict the prognosis of hepatocellular carcino
A GWAS-identified susceptibility locus on chromosome 11q13.3 and its putative molecular target for p
Polymorphism in protein tyrosine phosphatase receptor delta is associated with the risk of clear cel
Nuclear orphan receptor NR4A2 confers chemoresistance and predicts unfavorable prognosis of colorect
Establishment and characterization of clear cell renal cell carcinoma cell lines with different meta
Effect of functional nuclear factor-kappaB genetic polymorphisms on hepatitis B virus persistence an
Association between the various mutations in viral core promoter region to different stages of hepat
Non-coding RNAs in hepatitis B or C-associated hepatocellular carcinoma: Potential diagnostic and pr
Effect of Antiviral Treatment With Nucleotide/Nucleoside Analogs on Postoperative Prognosis of Hepat
Gene expression profiling-derived immunohistochemistry signature with high prognostic value in color
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular c
HLA-DP Polymorphisms Affect the Outcomes of Chronic Hepatitis B Virus Infections, Possibly through I
Prognostic significance and molecular mechanism of ATP-binding cassette subfamily C member 4 in resi
Hepatitis B Virus Combo Mutations Improve the Prediction and Active Prophylaxis of Hepatocellular Ca
Possible Mechanisms of Malignant Transformation of Nonresolving Inflammation Caused by Chronic Infec
期刊信息
位置：