中文摘要：

NR4A2 是属于类固醇孤儿的一个抄写因素原子受体总科。在 dopaminergic 神经原的产生和维护必要原来被认为，并且与象 Parkinsons 疾病那样的神经病学的混乱联系了。最近， NR4A2 被发现了在一些煽动性的疾病和癌症起一个关键作用。NR4A2 能由某 proinflammatory cytokines 是高效地激活 trans 的，例如肿瘤坏死因素 -- ， interleukin-1，和脉管的 endothelial 生长因素(VEGF ) 。表明小径的原子 factor-B 在有免疫力的房间用作可诱导的 NR4A 表示的一个主要管理者。NR4A2 罐头 trans 激活 Foxp3，明确地在规章的 T (Treg ) 房间表示的一个特点，和戏在 Treg 房间的区别，维护，和功能的一个关键角色。在 T 淋巴细胞的 NR4A2 为 Treg 房间正式就职和在生理、病理学的条件下面的 Th1 的异常正式就职的抑制是枢轴的。Foxp3+ Treg 房间的高密度显著地与胃肠的发炎，肿瘤免疫者逃跑，和疾病前进被联系。NR4A2 在 CD133+ colorectal 在高水平被生产癌(CRC ) 房间并且显著地由在周期的腺苷 monophosphate (营地) 的 cyclooxygenase-2-derived 前列腺素 E2 的 upregulated /protein kinase A (PKA ) 依赖者在 CRC 房间的举止。表明小径的 cAMP/PKA 是 NR4A2 相关的发炎和癌症的普通小径。NR4A2 trans 激活 osteopontin，与 CRC 侵略联系的 Wnt/-catenin 小径的一个直接目标，转移，和差的预后。内长的 NR4A2 击倒表示稀释导致 VEGF 的 endothelial 房间增长，移植并且在 vivo angiogenesis。一起拿， NR4A2 作为连接胃肠的发炎和癌症的一个重要原子因素出现，特别 CRC，并且应该用作一个候选人为发炎相关的胃肠的癌症的治疗学的目标。

英文摘要：

NR4A2 is a transcription factor belonging to the steroid orphan nuclear receptor superfamily.It was originally considered to be essential in the generation and maintenance of dopaminergic neurons,and associated with neurological disorders such as Parkinson＇s disease.Recently,NR4A2 has been found to play a critical role in some inflammatory diseases and cancer.NR4A2 can be efficiently trans-activated by some proinflammatory cytokines,such as tumor necrosis factor-α,interleukin-1β,and vascular endothelial growth factor（VEGF）.The nuclear factor-κB signaling pathway serves as a principal regulator of inducible NR4A expression in immune cells.NR4A2 can trans-activate Foxp3,a hallmark specifically expressed in regulatory T（Treg） cells,and plays a critical role in the differentiation,maintenance,and function of Treg cells.NR4A2 in T lymphocytes is pivotal for Treg cell induction and suppression of aberrant induction of Th1 under physiological and pathological conditions.High density of Foxp3 ＋ Treg cells is significantly associated with gastrointestinal inflammation,tumor immune escape,and disease progression.NR4A2 is produced at high levels in CD133 ＋ colorectal carcinoma（CRC） cells and significantly upregulated by cyclooxygenase-2-derived prostaglandin E 2 in a cyclic adenosine monophosphate（cAMP）/protein kinase A（PKA）-dependent manner in CRC cells.The cAMP/PKA signaling pathway is the common pathway of NR4A2-related inflammation and cancer.NR4A2 trans-activates osteopontin,a direct target of the Wnt/β-catenin pathway associated with CRC invasion,metastasis,and poor prognosis.Knockdown of endogenous NR4A2 expression attenuates VEGF-induced endothelial cell proliferation,migration and in vivo angiogenesis.Taken together,NR4A2 emerges as an important nuclear factor linking gastrointestinal inflammation and cancer,especially CRC,and should serve as a candidate therapeutic target for inflammation-related gastrointestinal cancer.