中文摘要：

目的观察肿瘤仿血管生成在骨肉瘤裸鼠移植瘤中的结构特点。方法建立荷人骨肉瘤裸鼠模型，切取肿瘤标本制作组织切片，应用CD147免疫荧光标记染色骨肉瘤细胞，观察骨肉瘤中肿瘤仿血管生成的结构特点。结果骨肉瘤细胞CD147染色呈阳性，在肿瘤中心区域可清楚观察到肿瘤仿血管结构。结论在骨肉瘤裸鼠移植瘤中存在典型的肿瘤仿血管通道，参与肿瘤的血液供应。

英文摘要：

Objective To study the construction features of vasculogenic mimicry in xenografts of human osteosarcoma cells in nude mice. Methods Vasculogenic mimicry in xenografts of human osteosarcoma cells in nude mice was constructed. The osteosarcoma cells and the construction features of vasculogenic mimicry were observed by immunohistochemical after CD147 staining. Results Osteosarcoma cells showed CD147 positive. The construction of vasculogenic mimicry was observed in the central zone of osteosarcoma. Conclusion Vasculogenic mimicry exists in xenografts of human osteosarcoma cell in nude mice. Tumor cells can obtain blood and nutrition by vasculogenic mimicry.