本文合成了一系列替比夫定3′-O-乙酰基-5′-O-苯基-N-烷基磷酰胺类化合物,用EI-MS,^1H NMR和^13C NMR确证了这些化合物的结果。我们评价了这些化合物在体外的活性。在合成的化合物中,化合物6d和6f的活性比替比夫定强。
A series of telbivudine 3′-O-acetyl-5′-O-phenyl-N-alkylphosphramidate derivatives have been synthesized and their structures were confirmed by El-MS, ^1H NMR and ^13C NMR. We evaluated their anti-HBV activity in vitro. Two compounds 6d and 6f, turned out to be more active than telbivudine.