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中文摘要：
化学生物学是一门化学与生命科学高度交叉的前沿学科,它利用化学的方法、手段和策略从分子水平认识生命现象的本质,创造对生理或病理过程具有调控作用的活性物质,从而为生物医药、农业和环境科学的发展提供解决方案.本文就厦门大学化学生物学学科近5年在生命有机磷化学、生化分析与生物传感等特色研究领域的进展进行综述.
英文摘要：
Chemical biology is a newly emerging interdisciplinary subject of chemistry and life sciences. It involves the use of chemical tools, principles, techniques,or approaches to study biological system （solve problems in biology） for a better understanding of molecular basis of life. It designs and synthesizes active compounds that play distinct roles in the regulation of physiological or pathological processes, and provides resources for the development of new ＆ advanced technologies in medicine, agriculture and environment and so on. This paper reviews the research progresses of the department in the areas of bioorganic phosphorus chemistry,bioanalysis and biosensing over the past five years.
同期刊论文项目
同项目期刊论文
Rapid, Absolute, and Simultaneous Quantification of Specific Pathogenic Strain and Total Bacterial C
Development of an Ultrasensitive Dual-Channel Flow Cytometer for the Individual Analysis of Nanosize
Detection and Quantification of Bacterial Autofluorescence at the Single-Cell Level by a Laboratory-
Size Differentiation and Absolute Quantification of Gold Nanoparticles via Single Particle Detection
Progress in the development of techniques based on light scattering for single nanoparticle detectio
A Covalent Reporter of -Lactamase Activity for Fluorescent Imaging and Rapid Screening of Antibiotic
Sensitive and Selective Bacterial Detection Using Tetracysteine-Tagged Phages in Conjunction with Bi
Cytosolic delivey of proteins mediated by aldehyde-displaying silica nanoparticles with pH responsiv
Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based s
Dual colored mesoporous silica nanoparticles with pH activatable rhodamine-lactam for sensing of lys
Stabilization of ssRNA on Graphene Oxide Surface: An Effective Way to Design Highly Robust RNA Probe
Cyclic enzymatic amplification method (CEAM) based on exonuclease III for highly sensitive bioanalys
Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins, and Small Molecules
Highly parallel single-molecule amplification approach based on agarose droplet polymerase chain rea
Synthesis of Uniform-Size Hollow Silica Microspheres through Interfacial Polymerization in Monodispe
Linear molecular beacons for highly sensitive bioanalysis based on cyclic Exo III enzymatic amplific
Pyrene-Excimer Probes Based on the Hybridization Chain Reaction for the Detection of Nucleic Acids i
Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by (31)P NMR and ESI-M
Copper-Catalyzed C-P Bond Construction via Direct Coupling of Phenylboronic Acids with H-Phosphonate
Stereospecific Coupling of H-Phosphinates and Secondary Phosphine Oxides with Amines and Alcohols: A
Determination of the Absolute Configuration of Pentacoordinate Chiral Phosphorus Compounds in Soluti
Isolation and purification of macrocyclic components from Penicillium fermentation broth by high-spe
Evaluation of non-covalent interaction between Seryl-Histidine dipeptide and cyclophilin A using NMR
Quantitative determination of zidovudine diaryl phosphate triester pro-drugs in rat plasma by high-p
Electrospray ionization multistage tandem mass spectrometry of penta- and hexa-substituted aryloxycy
Construction and ESI-MS Analysis of Homocyclic Peptide Libraries Assisted by Inorganic Phosphorus Re
A theoretical and mass spectrometry study of the novel mechanism of N-glycosidic bond cleavage in nu
Efficient Copper-Catalyzed Synthesis of 2-Amino-4(3H)-quinazolinone and 2-Aminoquinazoline Derivativ
Stereochemistry of chiral pentacoordinate spirophosphoranes correlated with solid-state circular dic
A universal platform for sensitive and selective colorimetric DNA detection based on Exo III assiste
Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain r
Graphene oxide-protected DNA probes for multiplex microRNA analysis in complex biological samples ba
Label-free visual detection of nucleic acids in biological samples with single-base mismatch detecti
Highly sensitive and quantitative detection of rare pathogens through agarose droplet microfluidic e
L -DNA molecular beacon: A safe, stable, and accurate intracellular nano-thermometer for temperature
One-Pot Synthesis of 5'-Diaryl Esters and Diamidates of Phosphate, Phosphorothioate, and Phosphorose
Copper-Catalyzed Synthesis of 1,2,4-Benzothiadiazine 1,1-Dioxide Derivatives by Coupling of 2-Halobe
N-phosphorylation of amino acids by trimetaphosphate in aqueous solution-learning from prebiotic syn
Copper-Catalyzed Aerobic Oxidative Coupling of Terminal Alkynes with H-Phosphonates Leading to Alkyn
Highly Efficient Iron(II) Chloride/N-Bromosuccinimide-Mediated Synthesis of Imides and Acylsulfonami
Easy Copper-Catalyzed Synthesis of Primary Aromatic Amines by Coupling Aromatic Boronic Acids with A
Chiral phosphoproline-catalyzed asymmetric Michael addition of ketones to nitroolefins: an experimen
Fast separation of antiviral nucleoside phosphoramidate and H-phosphonate diastereoisomers by revers
L-Valine assisted distinction between the stereo-isomers of D-hexoses by positive ion ESI tandem mas
Formation of cyclic acylphosphoramidates in mass spectra of N-monoalkyloxyphosphoryl amino acids usi
EVALUATION OF SINGLE-STRANDED OLIGONUCLEOTIDE CLEAVAGE FUNCTION OF SERYL-HISTIDINE DIPEPTIDE BY ELEC
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