中文摘要：

目的：了解青年（≤34岁）原发性干燥综合征（primary Sj gren syndrome,pSS）的发病形式和临床特点。方法：回顾性分析2004～2008年于北京大学人民医院风湿免疫科住院的232例pSS患者的首发症状、临床表现、实验室检查等。结果：青年发病（≤34）患者55例,占总患者数23.7%（55/232）,平均年龄（27.6±6.2）岁 中老年发病（〉34岁）患者177例,平均年龄（51.2±14.8）岁。青年组以口干和/或眼干为首发症状的仅占32.73%（18/55）,以非口干眼干的腺外器官受累首发的占67.27%（37/55） 中老年组有59.32%（105/177）以口干和/或眼干首发,40.67%（72/177）以腺外器官首发 两组首发症状差异有统计学意义（P=0.001）。青年组从出现症状至确诊为pSS时间明显长于中老年组[（93±107）个月vs（45±59）个月,P=0.001]。青年组患者的系统性损害发生率明显高于中老年组[61.8%（34/55）vs41.24%（73/177）,P=0.026]。结论：青年pSS发病患者中,约2/3以非口干和/或眼干为首发症状,出现症状到诊断时间间隔长,系统性损害发生率高于中老年组,在临床工作中应给予充分重视。

英文摘要：

Objective：To observe the clinical features of primary Sjogren syndrome （pSS） in young people （ ≤34 years）. Methods： The data of 232 patients with pSS who were in hospital from 2004 to 2008 were analysed in a prospective study. Results： A total of 23.7% （55/232）patients＇ symptoms came on in youth （ ≤34 years）, who were all females, mean age was （27. 6 ±6. 2） years. The other 177 patients＇ symptoms came on when they were more than 34 years old. In young group, 32. 73% （18/ 55） patients＇ first symptoms were xerostomia and/or keratoconjunctivitis sicca, the other 67. 27% （37/ 55 ）came on without xerostomia and keratoconjunctivitis sicca, while in the middle-aged and aged group, 59. 32% （105/177）patients＇ first symptoms were xerostomia and/or keratoconjunctivitis sicca, 40. 67% （ 72/177 ） without xerostomia and keratoconjunctivitis sicca. There was significant difference （ P = 0. 001 ）. The duration from first symptom to first diagnosis of pSS in the young group was （93 ± 107 ） months, which was significantly longer than those of the middle-aged and aged group [ （45 ± 59 ） months, P = 0. 001 ]. The systemic damage of the young group was 61.8% （34/55）, which was signifi- cantly greater than 41.24% （73/177） in the middle-aged and aged group（ P = 0. 026 ）. Conclusion： Pri- mary Sjogren syndrome in young people is not and/or keratoconjunctivitis sicca. Not only the young group is longer, but also the systemic rare, and about 2/3 of them come on without xerostomia duration from first symptom to first diagnosis of pSS in the damage of the young group is greater than those of the mid- dle-aged and aged group. These findings should alert the clinician to make the possible diagnosis of pSS in young patients.