中文摘要：

目的：探讨IL-6抗体治疗小鼠变应性鼻炎的作用。方法：实验动物分三组：PBS组（正常对照组）、抗IL-6抗体组（以抗IL-6单克隆抗体处理）、Ig G抗体对照组（以Ig G对照抗体处理）。应用卵清蛋白（OVA）致敏建立小鼠变应性鼻炎模型,给予抗IL-6单克隆抗体干预,计量抗原激发后小鼠搔鼻数量。应用HE染色方法检测对小鼠鼻黏膜炎症影响,应用ELISA法检测小鼠灌洗液中IL-4、IFN-γ含量。结果：治疗后抗IL-6抗体组小鼠搔鼻症状相对于抗体对照组明显减轻（P〈0.01）。与PBS组比较,Ig G抗体对照组小鼠鼻腔灌洗液中总炎性细胞数,淋巴细胞数及嗜酸性粒细胞数明显升高（P〈0.05）;IL-6抗体治疗后,小鼠鼻腔灌洗液中总炎性细胞数,淋巴细胞数及嗜酸性粒细胞数明显降低（P〈0.05）;Ig G抗体对照组小鼠鼻腔灌洗液IL-4含量明显升高（P〈0.01）,而IFN-γ含量不变（P〉0.05）;IL-6抗体治疗后,IL-4含量较Ig G抗体对照组降低（P〈0.05）,IFN-γ含量不变（P〉0.05）。结论：IL-6抗体可有效治疗小鼠变应性鼻炎。

英文摘要：

Objective： To explore the effect of anti-IL-6 in the treatment of allergic rhinitis in mice. Methods： A model of allergic rhinitis was established with Ovalbumin（OVA）, and then the mice were treated with anti-IL-6 or Ig G control antibody. The nasal rubs were counted. HE staining was performed and the number of different inflammatory cells was counted in the nasal lavage. The content of IL-4 and IFN-γ were measured by ELISA. Results： Compared to PBS group（normal control group）, the nasal rubs in the Ig G antibody control group was increased significantly（P〈0.01）, but after the treatment of anti-IL-6, the nasal rubs was decreased（P〈0.01）. Compared to PBS group, the total inflammatory cells, lymphoid cells and eosinophils showed significant difference for the Ig G antibody control group（P〈0.05）, but after the anti-IL-6 treatment, the number of these cells were significantly decreased（P〈0.05）. IFN-γ was not different among different groups（P〈0.05）. But after the anti-IL-6 treatment, the IL-4 production was significantly decreased（P〈0.05）.Conclusions： Anti-IL-6 treatment has therapeutic effect on the allergic rhinitis of mice.