中文摘要：

毒素-抗毒素系统（toxin-antitoxin system,TAS）是广泛存在于细菌和古细菌中的一类小型功能基因。目前已发现的TAS分为五大类型。超过75种乳酸菌（lactic acid bacteria,LAB）中的TAS被测定,TAS调控基因（改变细菌鞭毛类型、控制毒素毒性等）、应激环境下调节细菌代谢、在高浓度抗生素作用下形成持留细胞等调控机制已有较深入研究。本文概述近年来TAS分类发展及乳酸菌中TAS的研究情况,为深入研究乳酸菌中TAS并应用于食品工业提供理论依据。

英文摘要：

As a functional gene,toxin-antitoxin system（TAS） is present widely in bacteria and archaea.Five types of TAS have been discovered until now.The TAS in more than 75 species of Lactobacillus rhamnosus has been identified.TAS could regulate the genes such as changing the type of bacterial flagellum and controlling the toxicity of toxins,change the metabolism of bacteria under stress conditions,and metamorphose cells into persistent cells in medium with high concentration of antibiotics.In this review,we summarize recent progress in studying the TAS of L.rhamnosusin and its classification,aiming to provide a solid theoretical foundation for future research and application in the food industry.