中文摘要：

目的探讨中、重度慢性牙周炎与冠心病的相关性以及急性期蛋白成分纤维蛋白原（Fg）在其中的作用。方法选择不同牙周和心血管健康状态者共95人,分为健康对照（HC）组、牙周炎（MSP）组、冠心病（CHD）组和MSP＋CHD组,检测牙周临床指数、血浆Fg质量浓度和冠心病常规血清学指标,采用单因素方差分析和协方差分析法分析3种指标间的关系。结果4组研究对象的Fg质量浓度分别为（2.36±0.37）、（3.63±0.73）、（4.08±0.84）和（4.14±0.96）g/L,中、重度慢性牙周炎患者（MSP组和MSP＋CHD组）血浆Fg质量浓度明显高于HC组（P〈0.01）;排除血压和体重指数的影响后,中、重度慢性牙周炎患者发生CHD的可能性高于牙周健康者（OR=2.527,P=0.047）。结论中、重度慢性牙周炎可能是冠心病的危险因素,而Fg则可能是联系二者的生物学基础之一。

英文摘要：

Objective To investigate the correlation between moderately and severely chronic periodontitis and coronary heart disease, as well as the role of fibrinogen in the mechanisms responsible for the correlation between periodontitis and coronary heart disease. Methods 95 subjects who were systemic health or patients of coronary heart disease with or without periodontitis were enrolled. All the subjects were placed into 4 groups based on their periodontal status and cardiovascular health. The 4 groups were healthy control group （HC）, moderately and severely chronic periodontitis group（MSP）, coronary heart disease group（CHD）, and MSP coexisted with CHD group（MSP＋CHD）. Clinical periodontal index were examined, at the same time, plasma fibrinogen levels and serological changes used in diagnosing of cardiovascular disease routinely were determined. ANOVA and ANCOVA were used in the statistical analysis. Results Fibrinogen levels of HC, MSP, CHD, and MSP＋CHD group were （2.36±0.37）, （3.63±0.73）, （4.08±0.84）, and （4.14±0.96） g/L, respectively. Fibrinogen levels of MSP and MSP＋CHD group were significantly higher than that of healthy controls（P〈0.01）. The patients with moderately to severely chronic periodontitis were more likely to have coronary heart disease as compared to periodontally healthy controls （OR=2.527, P=0.047） after adjusted for blood pressure and body mass index. Conclusion Moderately and severely chronic periodontitis maybe a risk factor of coronary heart disease and fibrinogen could be one of the biological basis which links periodontitis with coronary heart disease.