中文摘要：

目的探讨血浆蛋白成分纤维蛋白原（Fg）在牙周病发病机制中的作用。方法体外培养口腔上皮细胞系KB细胞至单层融合，分别与不同浓度Fg溶液共同孵育，并加入以^3H-胸腺嘧啶核苷标记的牙龈卟啉单胞菌（Pg）行细菌感染攻击细胞实验。采用同位素闪烁光谱测定法检测黏附和内化于KB细胞的Pg数量。结果加入Fg的各实验组黏附和内化细菌量及细菌黏附和内化率均显著高于未加入Fg的对照组；不同Fg浓度的各组间黏附和内化细菌量及黏附和内化率差异亦有统计学意义，随着Fg浓度的升高，黏附和内化的细菌量显著增加。结论纤维蛋白原可促进Pg黏附于口腔上皮细胞，在牙周病的发生、发展中可能具有一定的病理学作用。

英文摘要：

Objective To study the role of fibrinogen molecule in the pathogenesis of periodontal diseases. Methods An in vitro cell culture model was used. Methyl-^3H Thymidine radiolabeled Porphyromonas gingivalis （Pg） ATCC 33277 were examined for their ability to adhere to and invade the confluent monolayers of human oral epithelial KB cells with or without exogenous human fibrinogens by scintillation spectrometry. Results The addition of exogenous fibrinogens made more amount of and higher ratios of adhesive and invasive Pg, in contrast to the group without exogenous fibrinogen （P 〈 0.001）. At different concentrations of exogenous fibrinogen, the amount and ratios of adhesive and invasive Pg varied significantly （P 〈 0.007）. The higher concentrations of exogenous fibrinogen was added, the greater amount and ratios of adhesive and invasive Pg were found. Conclusions Fibrinogen promotes the adherence of Pg to human oral epithelial cells and may play an important role in the pathogenesis of periodontal diseases.