中文摘要：

目的：分析莫西沙星治疗老年呼吸道感染的有效性与安全性，为提高该类患者的临床疗效提供参考依据。方法选取医院2012年1月－2013年12月收治的236例老年呼吸道感染患者，将其随机平分为莫西沙星治疗组（A组）和左氧氟沙星治疗组（B组），各118例，分别使用莫西沙星与左氧氟沙星治疗，对比分析两组患者的临床疗效、不良反应发生率以及治疗前后病原学检查结果；采用SPSS19．0软件对数据进行统计分析。结果 A组患者治疗有效率为94．9％，明显高于 B组的80．5％，两组比较差异有统计学意义（ P＜0．05）；A 组细菌清除率为91．2％，明显高于B组的69．7％，两组比较差异有统计学意义（ P＜0．05）；A、B两组患者不良反应发生率分别为6．78％和5．93％，差异无统计学意义，且症状均较轻微，经进一步治疗后即可痊愈。结论莫西沙星治疗老年呼吸道感染患者不良反应发生率低，临床见效快，且疗效显著，可缩短患者住院时间、节省就医成本。

英文摘要：

OBJECTIVE To observe the effectiveness and safety of moxifloxacin in treatment of the elderly patients with respiratory tract infections so as to improve the clinical efficacy in treatment of such group of patients . METHODS A total of 236 elderly patients with respiratory tract infections who were treated in the hospital from Jan 2012 to Dec 2013 were enrolled in the study and randomly divided into the moxifloxacin treatment group （the group A） and the levofloxacin treatment group （the group B） ,with 118 cases in each;the group A was treated with moxifloxacin ,while the group B was given the levofloxacin .The clinical efficacies ,incidence of adverse reac‐tions ,and results of etiological examination were observed and compared between the two groups ,and the statisti‐cal analysis was performed with the use of SPSS19 .0 software .RESULTS The effective rate of treatment of the group A was 94 .9% ,significantly higher than 80 .5% of the group B（P〈0 .05）;the bacterial clearance rate of the group A was 91 .2% ,significantly higher than 69 .7% of the group B（P〈0 .05） .The incidence of adverse re‐actions was 6 .78% in the group A ,5 .93% in the group B ,and there was no significant difference;all the patients had mild symptoms and were cured through further treatment .CONCLUSION Moxifloxacin can achieve significant clinical efficacy in treatment of the elderly patients with respiratory tract infections ,shorten the length of hospital stay ,and save the medical cost ,with the incidence of adverse reactions low .