中文摘要：

微小RNA（microRNA,miRNA）是一组长度为19-25个核苷酸的非编码RNA,在细胞增殖、分化、发育及死亡过程中发挥重要作用。在血浆中稳定存在并可检测的miRNA称为循环miRNA。近年来研究表明循环miRNA可作为诊断心肌病变的新型潜在生物标志物。本文就循环miRNA早期诊断心力衰竭、心肌梗死及药物性心脏毒性等心肌病变的临床与实验研究进展作一综述。

英文摘要：

MicroRNA（ miRNA） is a class of 19-25-nucleotide non-coding RNAs that plays an important role in cellular proliferation,differentiation,development as well as cell death. The miRNA that can be detected in the plasma is known as circulating miRNA,and it can exist stable in the circulation of the blood.Recently,circulating miRNA has been increasingly suggested as novel potential biomarkers of a series of myocardial lesions. This review article summarized the progress of clinical and experimental studies of circulating miRNA as early diagnosis index for cardiopathologic conditions,including acute myocardial infarction,heart failure along with drug-induced cardiotoxicity.