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中文摘要：
目的 研究片叶苔素D在大鼠体内的代谢，并对片叶苔素D在大鼠体内代谢产物进行分离与结构鉴定。方法 大鼠按40mg/kg剂量口服片叶苔素D后收集胆汁，采用高效液相色谱仪分离、纯化代谢产物，利用HPLC-MS/MS分析代谢产物，利用NMR鉴定结构。结果 大鼠口服片叶苔素D后，在胆汁中检测到2个Ⅱ相代谢产物，均为片叶苔素D与葡萄糖醛酸的结合产物（片叶苔素D-1’-O-β-D-吡喃葡萄糖醛酸），且两个代谢产物互为旋阻异构体，室温下可互相转化。结论 片叶苔素D在大鼠体内产生与葡萄糖醛酸结合的Ⅱ相代谢产物，且2个代谢产物互为旋阻异构体。
英文摘要：
Objective To investigate the metabolism pathway and identify the metabolites of riccardin D in vivo after oral administration in rats. Methods Using HPLC, the metabolites were purified from rats′ bile samples after oral administration of riccardin D 40mg/kg in rats. The structures of the metabolites were identified by HPLC-MS/MS and confirmed by NMR. Results The riccardin D′s metabolites were the conjugates with glucuronate and were identified as a mixture of two atropisomers. Conclusion The riccardin D′s main metabolism pathway in vivo is phase Ⅱ metabolism and the metabolites are the conjugate with glucuronate.
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