中文摘要：

EB病毒（EBV）是一种普遍存在的致癌病毒,是高度相关的淋巴和上皮肿瘤的来源和发展,包括伯基特淋巴瘤和鼻咽癌（NPC）等,EBV基因几乎可以在所有细胞中。EBV感染通常与少数潜伏病毒功能的蛋白质表达,包括潜伏膜蛋白LMP1和LMP2A等和巴尔核抗原1（EBNA1）。LMP1是肿瘤坏死因子受体超家族的成员,被认为是EBV的主要致瘤蛋白。在EB病毒中通过2个C末端结构域编码基因蛋白LMP1信号来驱动细胞生长,存活和转化。LMP1蛋白目前是惟一已被证实的EB病毒的癌基因,LMP1的表达参与了肿瘤的发生与发展,是目前癌症方面研究的重点。

英文摘要：

Epstein-Barr virus （EBV） is associated with several malignant diseases, including Burkitt＇ s lymphoma, nasopharyngeal carcinoma （NPC） and a portion of gastric cancers. EBV gene almost can exist in all cells. EBV infection is regarded as a type Ⅱ latent infection in which several genes, including the EBV nuclear antigen-1 （EBNA-1）, latent membrane proteins-1 and-2A （LMP1 and LMP2A）, BART microRNAs and EBV early RNA （EBER） may be expressed. LMP1, a member of the tumor necrosis factor receptor superfamily, is considered as a potent transforming protein of EBV. EBV encodes oncoprotein LMP1 signals through two C-terminal tail domains to drive cell growth, survival and transformation. LMP1 protein is the only cancer gene of EBV and the expression of LMPI is involved in the development of tumor.