中文摘要：

Mill Li received the PhD degree in computer science from Central South University, China, in 2008. She is currently a professor at the School of Information Science and Engineering, Central South University, Changsha, China. Her main research interests include bioinformatics and systems biology. Zhibei Niu is a masler student in computer science at Central South University. She received the bachelor degree from Central South University, China, in 2014. Her main research interests include biological network analysis and essential protein discovery. Xiaopei Chen is a master student in computer science at Central South University. Her main research interests include biological network analysis and essential protein discovery. She received the bachelor degree from Central South University, China. in 2013. E-mail：ping.zhong@csu.edu.cn.,Ping in Zhong received the PhD degree communication engineering flom Xiamen University, China, in 2011. She is currently a lecturer with the Department of Computer Science and technology at Central South University. Her research interests include machine learning, data mining, and networks protocol design. She is a member of ACM and IEEE. Fangxiang Wu received the BSc and MSc degrees in applied mathematics, both from Dalian University of Technology, China, in 1990 and 1993, respectively, the first PhD degree in control theory and its applications from Northwestern Polytechnical University, Canada, in 1998, and the second PhD degree in biomedical engineering from the University of Saskatchewan, Canada, in 2004. Currently, he is working as an associate professor of bioengineering with the Department of Mechanical Engineering and graduate chair of the Division of Biomedical Engineering at the University of Saskatchewan, Canada. His current research interests include systems biology, genomic and proteomic data analysis, biological system identilication and parameter estimation, and applications of control theory to biological system. Yi Pan is a Regents＇ Professor of computer scien