中文摘要：

背景：在细菌生物膜的形成过程中,密度感应系统发挥着重要的作用。大部分溴代呋喃酮与感应系统中的自诱导物受体结合后阻断了细菌的密度感应,但也有溴代呋喃酮与自诱导物受体结合后发挥了细菌自诱导物的作用,促进细菌生物膜形成。目的：比较不同类型溴代呋喃酮对聚氯乙烯材料表面表皮葡萄球菌生物膜形成的影响。方法：聚氯乙烯材料分为对照组和呋喃酮1-3组。对照组聚氯乙烯材料用乙醇浸泡5 min。呋喃酮1-3组分别使用化学结构具有代表性的3种溴代呋喃酮：3,4-二溴基-5-羟基-呋喃酮、4-溴-5-（4-甲氧基苯基）-3-（甲氨基）-呋喃酮和3,4-二溴基-5,5-二甲苯基-2（5H）-呋喃酮对聚氯乙烯材料进行表面涂层改性。将改性过的4组聚氯乙烯材料与表皮葡萄球菌共同培养。结果与结论：与对照组相比,呋喃酮2组聚氯乙烯材料表面表皮葡萄球菌群落数量较少少,细菌生物膜厚度较薄,培养18 h时聚氯乙烯材料表面无明显细菌生物膜结构形成;而呋喃酮1,3组表皮葡萄球菌群落数量和细菌生物膜厚度与对照组接近。说明不同溴代呋喃酮对聚氯乙烯材料表面表皮葡萄球菌生物膜形成的影响不同,其中4-溴-5-（4-甲氧基苯基）-3-（甲氨基）-呋喃酮可抑制聚氯乙烯材料表面表皮葡萄球菌生长和细菌生物膜形成。

英文摘要：

BACKGROUND： Quorum sensing system plays a very important role in the formation of bacterial biofilm. Most of brominated furanones blocked the quorum sensing of bacteria after combining with the receptors of autoinductors in sensing system, however, some brominated furanones play a role of bacterial autoinductors and promote the formation of bacterial biofilm. OBJECTIVE： To investigate the influence of different types of brominated furanones on the biofilm formation of Staphylococcus epidermidis on the surface of polyvinyl chloride materials. METHODS： Polyvinyl chloride materials were divided into control group and furanone 1-3 groups. The polyvinyl chloride materials in the control group were soaked with ethanol for 5 minutes. Three kinds of brominated furanones with representative chemical structure were taken as furanone 1-3 groups which were respectively 3,4-dibromo-5-hydroxyl-furanone,4-bromo-5-（4-methoxypheny）-3-（methylamino）-furanone and 3,4-dibromo-5,5-dimethoxypheny-2（5H）-furanone. The surface coating of the polyvinyl chloride materials in these four groups all underwent modification and then were co-cultivated with Staphylococcus epidermidis together. RESULTS AND CONCLUSION： Compared with the control group, Staphylococcus epidermidis bacterium community quantity on the surface of polyvinyl chloride material was smaller, and the thickness of bacterium biofilm in furanone-2 group was thinner. There was no obvious bacterial biofilm structure formation on the surface of polyvinyl chloride material at the 18 th hour of culture. The Staphylococcus epidermidis bacterium community quantity and the thickness of bacterium biofilm in furanone 1 and furanone 3 groups were closer to the control group. These results show that the impact of different types of brominated furanones on biofilm formation of Staphylococcus epidermidis on the surface of polyvinyl chloride materials is different, among them, 4-bromo-5-（4-methoxypheny）-3-（methylamino）-furanone can inhibit the growth of Staphylococcu