中文摘要：

目的：探讨治疗急性心力衰竭大鼠的最佳给药方法。方法：选取健康雄性大鼠80只,以随机数字表法分为空白对照组、模型组、附子一号组、干姜一号组、姜附一号组、附子二号组、干姜二号组、姜附二号组等8组,每组各10只。附子一号组、干姜一号组、姜附一号组大鼠按20 ml/kg灌胃给予相应药液,模型组大鼠灌胃给予同体积纯水,1日1次,连续7 d;附子二号组、干姜二号组和姜附二号组于造模成功后一次性给予药物。于一号组末次给药后,观察不同给药方法对急性心力衰竭大鼠血流动力学参数、心肌组织以及B淋巴细胞瘤-2基因（Bcl-2）、Bcl-2相关X蛋白（Bax）和动力相关蛋白1（Drp1）的影响。结果：血流动力学结果显示,姜附的缓解作用显著大于单用附子,同时,一号组大鼠各指标改善率普遍高于二号组;心肌组织病理学显示,姜附改善大鼠心肌组织损伤的病理变化作用优于附子,此外,附子、姜附一号组大鼠个指标缓解率显著优于二号组;Bax、Bcl-2以及Drp1的核酸水平显示,附子、干姜以及姜附一号组大鼠各指标缓解率均大于二号组,且姜附组优于附子及干姜单独给药组。结论：对于急性心力衰竭大鼠模型而言,预防性给药的效果优于一次性给药,提示相关实验可采纳预防与治疗结合的给药方法。

英文摘要：

OBJECTIVE： To probe into the optimized administration methods in treatment of acute heart failure in rats. METHODS： 80 healthy male rats were randomly selected to be divided into blank control group,model group,monkshood group one,dried ginger group one,ginger and monkshood group one,monkshood group two,dried ginger group two,ginger and monkshood group two via the random number table,with 10 cases in each. Monkshood group one,dried ginger group one,ginger and monkshood group one were given 20 ml / kg corresponding liquid by intragastric administration. model group received the same volume of water by intragastric administration,one time one day,a continuous 7 d. Monkshood group two,dried ginger group two,ginger and monkshood group two were gived single medication after modeling successfully. After the last administration of group one,effects of different administration methods on hemodynamics parameters, myocardial tissue and Bcl-2, Bax and Drp1 of acute heart failure rats.RESULTS： According to results of hemodynamic,ginger and monkshood appended significantly greater than monkshood alone,meanwhile,the improvement rate of various indicators in the 1st group was generally higher than those of the 2nd group. According to the myocardial tissue pathology,the effects of ginger and monkshood in improving the pathological changes of myocardial tissue damage were better than those of monkshood,in addition,the remission rate of various indicators of monkshood group one,dried ginger group one,ginger and monkshood group one were better than those of group two,and ginger and monkshood group was better than monkshood group and dried ginger group. CONCLUSIONS：In terms of the rat model of acute heart failure,prophylactic administration is better than a one-time administration,which suggests that experiments can adopt the method of administration of the combination of prevention and treatment.