中文摘要：

目的考察连翘酯苷在大鼠胃、肠道内的吸收动力学特征。方法采用大鼠胃肠吸收模型,用HPLC测定胃、肠灌注液中连翘酯苷的浓度。结果连翘酯苷在大鼠胃、十二指肠、空肠、回肠及结肠中每小时吸收率分别为6.36%、8.38%、8.19%、9.10%、6.91%。结论连翘酯苷在大鼠胃肠道内无特定吸收部位,吸收呈线性动力学过程,吸收机理为被动扩散。

英文摘要：

OBJECTIVE To investigate the absorption kinetics of forsythiaside in rat stomach and intestine.METHODS The drug concentration by in situ perfusion in rats was determined by HPLC.RESULT The hourly absorption percentages of forsythiaside in stomach,duodesum,jejunum,ileum and colon were 6.36%,8.38%,8.19%,9.10% and 6.91%,respectively.CONCLUSION Forsythiaside has no specific absorption site in rat gastrointestinal tract.Drug absorption was a linear dynamics with facilitated diffusion mechanism.