中文摘要：

目的研究双黄连口服制剂中连翘有效成分的吸收调控。方法采用HPLC法测定大鼠在体实验中连翘苷和连翘酯苷的含量,采用大鼠在体肠实验方法分别进行了整方和拆方的研究。结果连翘苷几乎无吸收。绿原酸能显著改善连翘酯苷在大鼠体内的吸收速度和程度。结论双黄连制剂中,金银花能显著改善连翘酯苷的吸收,提示中药组方的合理性。

英文摘要：

OBJECTIVE To study the absorption characters and mechanism of phillyrin and forsythiaside in Shuanghuanglian oral preparations.METHODS The concentration of phillyrin and forsythiaside were determined by HPLC,the absorption mechanism was investigated by using an in situ intestine experiment model.RESULTS The concentration of phillyrin in perfusion solution changed little which indicated that the compositions in Shuanghuanglian oral preparations could not improve the absorption of phillyrin.But the absorption extent and rate of forsythiaside were obviously improved after combined with Flos Lonicerae.CONCLUSION Flos Lonicerae significantly increases the absorption of forsythiaside which indicates the rationality of traditional Chinese medicine prescription.