中文摘要：

肥胖已经成为严重危害人类健康的社会问题。目前已筛选到部分与肥胖相关的基因，其中磷酸三酯酶相关基因（phosphotriesteraserelatedgene，PTER）被认为与肥胖具有一定的相关性。PTER基因在脂肪组织中高表达，在脂肪的蓄积过程r11起到重要的作用，并且与肥胖的程度及其衡量指标有一定的相关性，PTER单核苷酸多态性（rsl0508503）与肥胖及各肥胖指征亦有明显的相关性。另外，PTER可导致体内瘦素浓度的变化，进一步促进肥胖的发生。本文在介绍PTER的发现及组织表达特性的基础上，综述了该基因与肥胖和瘦素的关系，并对其今后的研究方向做一展望。

英文摘要：

Obesity has become a global health issue across all age groups and ethnics groups. Hundreds of candidate genes for obesity susceptibility including phosphotriesterase related gene （PTER）have been identified. PTER is highly expressed in adipose tissue,consequently implying a role in the accumulation of fat mass,and significantly associated with the degree of obesity and other obesity-related traits. Its variant, the single nucleotide polymorphism（rs10508503）,does seem to influence obesity and obesity-related traits in the general population. Otherwise, PTER shows suggestive evidence for linkage of serum leptin levels. The relationship between PTER, obesity and leptin are reviewed in this paper.