中文摘要：

目的探讨柯萨奇B组病毒（CBV）感染与成人隐匿性自身免疫性糖尿病（LADA）的关系。方法采用1：2配比病例对照研究，以ELISA法对LADA、T2DM和非糖尿病（non-DM）组研究对象进行血清CBVIgM和IgG抗体检测。结果LADA、T2DM和non-DM三组CBVIgM抗体阳性率（分别为6．3％、2．1％和5．2％）及IgG抗体阳性率（分别为14．6％、9．4％和12．5％）的差别均无统计学意义；条件logistic回归分析也未发现血清CBVIgM和IgG抗体与LADA之间有统计学联系。结论本研究未发现血清CBVIgM和IgG抗体与LADA相关。

英文摘要：

Objective To explore the association between coxsackie B virus （CBV） infection and latent autoimmune diabetes in adults （LADA）. Methods A 1：2 matched case-control study was conducted in Tianjin in 2005. The serum IgM and IgG antibodies for CBV were determined by enzymelinked immunosorbent assay. Results The positive rates of antibodies for CBV were 6.3%, 2.1% and 5.2% （IgM Ab） and 14.6%, 9.4% and 12.5% （IgG Ab） in LADA patients, T2DM patient controls and non-diabetes controls respectively. There were no significant differences in the positive rates of IgM and IgG antibodies for CBV among three groups. The results of conditional logistic regression analysis showed that no association of serum IgM and IgG antibodies for CBV with LADA was found. Conclusions No association of serum IgM and IgG antibodies for CBV with LADA is found.