中文摘要：

腺苷酸转运体（ANT）是核基因编码的位于线粒体内膜的双功能蛋白质,其生理功能是将胞浆中的ADp与线粒体的ATP以1：1进行交换.当其功能障碍时,影响细胞能量代谢,导致疾病或病情加重,与扩张型心肌病、进行性眼外肌麻痹等关系密切;ANT又是线粒体通透性转换孔的重要组成部分,参与调节线粒体通透性转换孔的开闭,与细胞凋亡关系密切.

英文摘要：

Adenine nucleotide transporter （ANT） is a nuclear-encoded protein, which located on the inner membrane of mitochondria. ANT catalyzes the import of cytosolic ADP and the export of matrix ATP with identical rate during physiological state. Dysfunction of the mitochondrial ADP/ATP carrier can result in severe disorders such as dilated cardiomyopathy, progressive external ophthalmo, etc. However, ANT also constitutes a core component of the mitochondrial permeability transition pore and is related to the apoptosis.