中文摘要：

目的利用静息态功能连接磁共振技术，观测静息态下复发-缓解型多发性硬化（relapsing remitting multiple sclerosis，RRMS）患者左、右侧海马与全脑的功能连接。方法19例RRMS患者与19例年龄、性别相匹配的健康者接受静息态功能磁共振成像扫描，分别选择左、右侧海马为种子点。分析其与全脑的功能连接。结果RRMS患者左侧海马与左侧海马旁间（brodmannarea36，BA36）功能连接减低，左侧海马与左后侧小腑、右侧额中回（BA9）、右侧额下回（BA47）、右侧缘上回（BA40）功能连接增强；右侧海马与左后侧小脑功能连接增慢。双侧的海马功能连接异常区域与PASAT评分、EDSS评分及病程均无明显相关性（P〉0．05）。结论RRMS患者海马与广泛的皮质及皮质下结构存在功能连接异常，其改变可能与患者异常认知功能有关，初步描绘了RRMS患者静息念下海马功能连接模式。

英文摘要：

Objective To evaluate funclional connectivity of hippocampus in patients with relapsing remitting multiple sclerosis （RRMS） by resting-state functional magnetic resonance imaging（rs-fMRI）. Methods Nineteen RRMS patients and 19 age-,and sexmatched heahhy controls（HCs） were scanned by Siemens Trio 3.0 T functional MRI in resting state. Regions of interest（ROI） based functional connectivity analysis was employed to identify the potential ahered in functional connectivity of bilateral hippocampus between two groups. Results In RRMS group,the left hippocampus-ROIs showed decreased functional connectivity to left parahippocampal gyrus（brodmann area36,BA36）;increased functional connectivity to left rear side cerebellar, right middle frontal gyrus （BAg）,right inferior frontal gyrus（BA47） and right supramarginal gyrus（BA40）. We also found that the right hippocampus-ROIs showed increased functional connectivity to left rear side cerebeilar. However,there was no significant correlation between the paced auditory serial addition test （PASAT） scores, lhe expanded disability status scale （EDSS） scores,disease duration and the abnormally functional connections of bilateral hippocampus in RRMS group. Conclusion The results provide evidence that abnormal resting-state functional connections linking the hippoeampus to cortical and sub-cortical regions may be involved in the underlaying pathology of a series of cognitive dysfunction in RRMS. This mode is the preliminarily describe by resting-state functional connectivity of hippocampus in RRMS.