中文摘要：

目的探讨血清25羟维生素D3[25（OH）D3]水平与2型糖尿病患者下肢血管病变（LLPAD）的关系。方法选取210例2型糖尿病患者（T2DM组）,根据下肢血管超声结果将患者分为LLPAD组（94例）和无下肢血管病变（Non-LLPAD）组（116例）,并选取同期来本院体检的50例健康者为对照组。对每位患者进行临床资料收集及常规生化指标检测,采用电化学发光法检测所有受试者血清25（OH）D3水平。结果 LLPAD组患者血清25（OH）D3水平显著降低,与Non-LLPAD组比较差异有统计学意义（P〈0.05）。多因素Logistic回归分析发现年龄（OR=1.064,P=0.001）、吸烟（OR=3.639,P=0.001）、舒张压（OR=1.046,P=0.010）、糖化血红蛋白（HbA1c）（OR=1.188,P=0.048）、低密度脂蛋白胆固醇（LDL-C）（OR=1.520,P=0.028）、25（OH）D3（OR=0.096,P=0.001）是糖尿病下肢病变的独立危险因素。结论低维生素D水平、高龄、吸烟、高HbA1c、高舒张压、高LDL-C与2型糖尿病患者LLPAD的发生密切相关。

英文摘要：

Objective To explore the relationship between 25-hydroxyvitamin D3 [25（OH）D3,VD] and lower limb peripheral arterial disease（LLPAD）. Methods A total of 210 type 2 diabetic patients and 50 non-diabetic healthy subjects were enrolled in this study.All the diabetic patients underwent u1trasonography and were divided into 2 groups[LLPAD group（n=94） and non-LLPAD group（n=116）].Clinical data were collected,routine biochemical indices were determined,and serum VD were measured in the diabetic patients and the non-diabetic healthy subjects. Results VD levels decreased significantly in the LLPAD group,with statistically significant differences from the non-LLPAD group（P0.05）.Multivariate logistic regression revealed that age（OR=1.064,P=0.001）,smoking（OR=3.639,P=0.001）,DBP（OR=1.046,P=0.010）,HbA1c（OR=1.188,P=0.048）,LDL-C（OR=1.520,P=0.028） and serum VD（OR=0.096,P=0.001） were independent risk factors for LLPAD among diabetic patients. Conclusion The development of LLPAD is closely related to old age,smoking,DBP,increased levels of HbA1c,LDL-C,and decreased level of serum VD.