中文摘要：

目的：探讨个体差异因素对针刺腧穴脑功能性磁共振成像的影响,并进一步分析引起个体差异的可能因素。方法：选取健康志愿者26例,针刺左侧足三里,平补平泻法,采用相同的试验设计及数据采集参数进行功能数据采集,然后采用相同的数据处理方法进行个体数据分析,并且剔除不符合数据分析条件的数据。对于符合条件的26例个体数据,按照随机分组的原则,分别随机抽取5次,分别得到A、B、C、D、E 5组样本,每组抽取的样本量均为11例。采用AFNI软件对每组数据进行分析,分别得出不同分组的脑功能激活区定位结果。结果：A、B、C、D、E 5组均见不同程度脑内活动区,但不同组之间结果差异很大,C组脑内活动区表现为信号减低,D组脑内活动区表现为信号增高,A、B、E组则表现为部分区域信号减低,部分区域信号增高;D组脑内激活区与其他各组完全不同。不同组间激活区不同率为46.7%～100.0%,大多数组间差异都超过一半脑内激活区。结论：在严格控制试验设计、针刺方法、数据采集参数以及数据处理方法的前提下,同一组被试的不同随机分组得出的脑功能激活区差别巨大,说明不同个体之间的针刺脑功能激活区存在着显著的个体差异,这种个体差异有可能会明显影响针刺脑功能成像的研究结果以及基于这些研究结果得出的结论。

英文摘要：

Objective Effects of inter-individual variability on fMRI of acupuncture were observed and the possible influencing factors were further analyzed.Methods Twenty-six healthy volunteers were selected.And acupuncture was applied at Zusanli（ST 36） on the left side with even manipulation.The same experimental designation and data collecting reference were adopted to collect functional data.Then,the same data processing method was applied for analyzing individual data.Data which did not confirm with data analyzing qualification were rejected.The 26 individual data which met the requirement were taken randomly for 5 times according to the principle of random group division.Five groups named with A,B,C,D and E were thus generated with 11 samples in each.Images were processed with the AFNI software for every group,and the activated brain areas were revealed.Results Activated areas in the brain were observed in all the 5 groups,and the results vary a lot among different groups.Decreased signals of activated brain areas were observed in group C,while increased signals were seen in group D.Partial increasing and partial decreasing signals appeared in the other 3 groups.Compared with other groups,group D demonstrated totally different activated areas.The rate of difference among different groups is 46.7%-100.0%,and most of the differences were over half of the activated areas.Conclusion Under the prerequisites of strict control of experimental designation,acupuncture method,data collecting and processing,great differences have been found in the activated areas of the brain.It indicates that obvious individual differences existes in the activated areas of the brain with acupuncture.And the difference may greatly influence the researching result of fMRI as well as conclusions of those results.