目的:系统评价电针治疗脑卒中后认知障碍(post-stroke cognitive impairment,PSCI)的疗效与安全性。方法:计算机检索中国知网数据库(CNKI)、中国生物医学文献数据库(CBM)、万方数据库(WanFang)、维普全文期刊数据库(VIP)、PubMed及The Cochrane library数据库中有关电针治疗PSCI的所有随机对照试验(randomized control trials,RCTs),检索时间为建库至2016年10月。由2名研究者独立地进行文献筛选与资料提取,采用Cochrane系统评价手册方法对纳入研究进行质量评价,采用RevMan 5.3软件进行Meta分析。结果:总共纳入14项RCTs,合计896例PSCI患者。Meta分析显示,电针组在改善PSCI患者简易精神状态检查量表(MMSE)积分[MD=1.78,95%CI(0.24,3.32),P=0.02]、蒙特利尔认知评定量表(Mo CA)积分[MD=1.92,95%CI(0.96,2.88),P〈0.000 1]、P 300潜伏期[MD=-11.01,95%CI(-18.91,-3.11),P=0.000 6]、P 300波幅[MD=1.56,95%CI(1.14,1.98),P〈0.00001]、Fugl-Meyer运动功能量表(FMA)积分[MD=10.74,95%CI(2.67,18.82),P=0.009]、临床疗效[RR=1.37,95%CI(0.98,1.91),P=0.06]方面优于对照组;在日常生活能力的改善方面,电针组疗效与对照组比较差异无统计学意义[MD=6.38,95%CI(-2.41,15.18),P=0.15]。结论:本次系统评价证实电针治疗PSCI有效且安全性较可靠,电针可改善PSCI患者认知功能、运动功能,但由于本次纳入文献质量较低,仍需更多设计合理的多中心RCT研究加以验证。
Objective To systematically evaluate the efficacy and safety of electroacupuncture(EA) for post stroke cognitive impairment(PSCI).Methods The randomized clinical trials(RCTs) regarding EA for PSCI published before October of 2016 were researched in China National Knowledge Infrastructure(CNKI),Chinese Biomedical Database(CBM),Wan Fang database,VIP medicine information system,Pub Med and Cochrane Library.The literature screening and information extraction was conducted by two independent reviewers.The quality assessment was performed based on the guidance of the Cochrane Reviewers' Handbook,and Meta-analyses was performed by using RevMan 5.3 software.Results Totally 14 RCTs were included,involving 896 PSCI patients.The results of Meta-analyses showed the EA group was superior to the control group in improving the MMSE [MD =1.78,95% CI(0.24,3.32),P =0.02],the MoCA [MD=1.92,95% CI(0.96,2.88),P〈0.000 1],P300 latency [MD =-11.01,95% CI(-18.91,-3.11),P =0.000 6],P300 amplitude [MD=1.56,95% CI(1.14,1.98),P〈0.000 01],FMA score [MD =10.74,95% CI(2.67,18.82),P =0.009] and the clinical effective rate [RR =1.37,95% CI(0.98,1.91),P =0.06].However,the comparison of BI score in both group had no significant differences [MD =6.38,95% CI(-2.41,15.18),P =0.15].Conclusion This Meta-analyses confirmed EA is effective and safe for PSCI,which could improve cognitive function and motor function.However,because of low quality of the included studies,more well-designed multicenter RCTs are needed.