对拟除虫菊酯类(SPs)农药对哺乳动物的神经毒理学研究过程及其最新进展进行了综述。拟除虫菊酯类农药是目前使用广泛的一类神经毒性杀虫剂,主要用于农业和卫生害虫的防治。已有研究结果显示拟除虫菊酯类农药对非靶标野生动物和人类的神经系统有一定的毒性作用,其对哺乳动物的神经毒性主要表现为急性和慢性神经毒性,而且其毒性作用与拟除虫菊酯类农药的立体结构相关,有一定的对映体选择性差异。
The research advances of synthetic pyrethroids (SPs)in the toxicity to mammal nervous systems were reviewed. SPs are widely used in both agricultural and urban environments for insect control. Some studies showed that SPs display toxicity to wildlife and human nervous systems. It may cause acute and chronic neurotoxicity to mammal, and the stereoisomeric structure of SPs affects mammals neurotixicity. There was some enantioselectivity of SPs in acute and chronic neurotoxicity to mammal.