中文摘要：

阿尔茨海默病是老年痴呆最常见的病因，而胆固醇分布及代谢均可能影响阿尔茨海默病（AD）发病。全基因组相关性研究（GWAS）揭示载脂蛋白E基因（APOE）、簇连蛋白（CLU）、补体受体1（CRl）、磷脂酰肌醇结合网格蛋白装配蛋白（PICALM）及桥连整合蛋白1（BINl）等基因与AD有关，而在AlzGene荟萃分析中有五个胆固醇相关基因结果呈阳性，分别是APOE、胆固醇-25-羟化酶（CI-125H）、CLU、低密度脂蛋白受体（LDLR）及分拣蛋白相关受体1（SORLl）。本文旨在探讨上述基因在脂质代谢中的潜在作用以及对AD发病机制可能的影响。

英文摘要：

Alzheimer＇ s disease （AD） is the most common cause of senile dementia,and both of the distribution and metabolism of cholesterol may affect the pathogenesis of AD. Genome-wide association study （GWAS） have revealed five genes associated with AD, including apolipoprotein E （APOE）, clusterin （ CLU）, complement receptor 1 （ CR1 ）, pbosphatidylinositol-binding clathrin assembly protein（PICALM） and bridging integrator protein 1 （ BIN1 ）. However, five cholesterol-related genes which have been reported association with AD, have positive results in meta-analysis of AlzGene, respectively, APOE, cholesterol 25-hydroxylase （ CH25H ）, CLU, low density lipoprotein receptor （LDLR） and sortilin-related receptor precursor（SORL1 ）. This paper aims to explore the potential role of these genes in lipid metabolism and the potential affection in the pathogenesis of AD.