中文摘要：

目的：探讨黑素瘤抑制性活性因子（MIA）在黑素瘤及基底细胞癌中的表达及其作用。方法：应用sP免疫组化技术检测38份黑素瘤石蜡标本、35份基底细胞癌石蜡标本以及32份色素痣石蜡标本中MIA的表达水平。结果：MIA在所有色素痣以及基底细胞癌中均呈阴性表达，而在原位黑素瘤、侵袭性黑素瘤、有淋巴结转移的黑素瘤、无淋巴结转移的黑素瘤阳性表达率分别为21．4％、91．6％、94．1％和42．8％。结论：MIA在黑素瘤的发生发展中起重要作用，MIA有可能成为临床诊断、治疗黑素瘤的靶点。

英文摘要：

Objective： To investigate the expression and the role of melanoma inhibitory activity （MIA） in the pathogenesis of malignant melanoma and basal cell carcinoma. Methods： The expression of MIA protein was determined by SP immunohistochemistry from specimens of 38 patients with malignant melanomas, 35 basal cell carcinoma and 32 benign melanocytic nevi. Results： MIA was negative in benign melanocytic nevi and basal cell carcinoma, while positive in 21.4% melanomas in situ, 91.6% invasive melanomas, 94.1% metastatic melanomas, and 42.8% melanomas without metastasis. Conclusions： These findings suggest that MIA may be related to the development of malignant melanoma. MIA may be a new target for the therapeutic intervention of malignant melanoma.