中文摘要：

乳酸杆菌为应用最早、研究最多的益生菌种之一，能够调节肠道微生物区系的平衡，增强机体的免疫力和抵抗力。S-层蛋白在乳酸杆菌黏附过程中起重要作用，因此乳酸杆菌中的S-层蛋白成为研究热点。本文对乳酸杆菌S-层蛋白的结构、分离提纯方法、基因克隆情况和益生功能做了详细阐述。

英文摘要：

Lactobacilli, one of the most common members of intestinal microbiota, have been applied and studied considerably. Because it can regulate the host intestinal microbiota balance and improve the immunity and resistance of host. Lactobacillus surface layer proteins （S-layer proteins） have been a research hotspot for playing an important role in the adhesion to the host. Here we summarize the advances in researches about the structure, the method of separation and purification, the situation of gene cloning and the probiotic functions of S-layer protein.