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不同容量液体对失血性休克家兔早期复苏效果的影响
  • ISSN号:1009-881X
  • 期刊名称:《中国血液流变学杂志》
  • 时间:0
  • 分类:R331.35[医药卫生—人体生理学;医药卫生—基础医学] R605.971[医药卫生—急诊医学;医药卫生—临床医学;医药卫生—外科学]
  • 作者机构:[1]河北北方学院微循环研究所,河北张家口075029
  • 相关基金:国家自然科学基金资助项目(30770845);河北省自然科学基金资助项目(C2008000503):张家口市科学技术研究与发展指导计划项目(0801019D)
中文摘要:

目的观察不同容量液体复苏对失血性休克家兔复苏即刻重要器官体系数、血液流变学指标的影响。方法27只健康实验家兔随机均分3组,颈总动脉放血复制家兔失血性休克模型。休克20min后将放出的全血加等倍生理盐水(1:1复苏组)或放出的全血加2倍生理盐水(1:2复苏组)行液体复苏,并设对照组。液体复苏后,观察重要器官体系数、血液流变学指标的变化。结果经不同容量液体复苏后,两组动物血压基本恢复正常;1:1复苏组复苏即刻的肝系数小于对照组与1:2复苏组(P〈0.01),三组间的心、肾、肺系数无统计学差异(p〉0.05);1与1:2复苏组各切变率下的全血粘度均显著低于对照组(p〈0.01),三组间的血浆粘度与相对粘度无统计学差异(P〉0.05)。结论失血性休克行液体复苏后.能较好地恢复血容量,但全血粘度及肝系数下降;休克早期的低粘血症,值得重视。

英文摘要:

Objective To investigate the effects of the different volumes of fluid resuscitation on the vital organs coefficients and hemorheological indexes of immediately recoveried hemorrhagic shock rabbits.Methods 27 healthy rabbits were divided into three groups randomly,with reproduct of the model of hemorrhagic shock by bleeding the carotid artery.After shocking 20 minutes,all bleeding and commensurable noraml saline (1: 1 resuscitation group), or all bleeding and 2 times normal saline (1:2 resuscitation group) were used for fluid resuscitation, and the control group were set up.After fluid resuscitation, the changes of vital organs coefficients and hemorheological indexes were observed.Results After different volumes of fluid resuscitation, the two model groups returned to normal blood pressure, the liver coefficient of the l:l resuscitation group was lower than that of the control group and 1:2 resuscitation group (P〈0.01), and the heart, kidney, lung coefficients had no statistical difference among the three groups (P〉0.05). The whole blood viscosity of the two resuscitation groups were less than the control group (P〈 0.0!), plasma viscosity and relative viscosity had no statistical difference among the three groups (P〉0.05). Conclusion The fluid resuscitation after hemorrhagic shock could do good to restore blood volume, but the whole blood viscosity and hepatic coefficient were decreased.Attention shonld be paid to low viscosity anemia on shock early stage.

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期刊信息
  • 《中国血液流变学杂志》
  • 主管单位:中国科学技术协会
  • 主办单位:中国生物医学工程学会 苏州大学
  • 主编:王天佑
  • 地址:苏州市人民路708号
  • 邮编:215007
  • 邮箱:
  • 电话:0512-65122060
  • 国际标准刊号:ISSN:1009-881X
  • 国内统一刊号:ISSN:32-1625/R
  • 邮发代号:
  • 获奖情况:
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  • 被引量:8969