一系列聚碳酸酩共聚物被 ɛ-caprolactone (CL ) 和 2-phenyl-5,5-bis (oxymethyl ) 的帮助微波的戒指洞聚合综合作为催化剂与听(II ) 2-ethylhexanoate 整修乙烯碳酸盐(PTC ) 。获得的这些共聚物被 1 H NMR,英尺红外,紫外,胶化浸透层析(GPC ) ,微分扫描热量测定(DSC ) 和自动接触角度米。单体,催化剂集中,反应时间和反应温度,以及 copolymerization 过程上的微波照耀力量的臼齿的比率也是的 feed 的影响学习了。在 vitro,降级测试显示这些聚碳酸酩共聚物拥有慢降级率和强壮的 hydrophobicity。在 vitro,从共聚物的 5-Fu 的版本侧面证明共聚物让稳定的药释放率和好控制版本性质。
A series of polycarbonate copolymers were synthesized by microwave-assisted ring-opening polymerization of ε-caprolactone (CL) and 2-phenyl-5,5-bis(oxymethyl) trimethylene carbonate (PTC) with Tin (Ⅱ) 2-ethylhexanoate as a catalyst. These copolymers obtained were detected by 1H NMR, FT-IR, UV, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and automatic contact angle meter. The influences of the feed molar ratio of monomers, catalyst concentration, reaction time and reaction temperature, as well as microwave irradiation power on the copolymerization process were also studied. In vitro degradation tests indicated that these polycarbonate copolymers possess the slow degradation rates and strong hydrophobicity. In vitro release profiles of 5-Fu from copolymers showed that copolymers have the steady drug release rates and good controlled release properties.