中文摘要：

建立了毛细管电泳-安培检测法测定盐酸去氧肾上腺素（phenylephrine hydrochloride,PHE）、重酒石酸间羟胺（metaraminol bitartrate,MR）和盐酸异丙肾上腺素（isoprenaline hydrochloride,IP）3种拟肾上腺素药物的方法。检测电位为0.950V（Ag/AgCl为参比电极）,硼酸盐浓度为50mmol/L（pH10.00）,分离电压为18kV,进样时间为10s。在最佳实验条件下,3种物质在18min内达到基线分离,在2～100μmol/L浓度范围内峰面积与浓度呈良好的线性关系,线性相关系数不小于0.9991。盐酸去氧肾上腺素、重酒石酸间羟胺和盐酸异丙肾上腺素的检出限分别为0.8、0.8和1.0μmol/L。将所建立的方法应用于针剂样品的分析,结果令人满意。

英文摘要：

A method for the determination of three adrenergic drugs,including phenylephrine hydrochloride（PHE）,metaraminol bitartrate（MR）and isoprenaline hydrochloride（IP）,was developed using capillary electrophoresis with amperometric detection.The detection potential of working electrode was 0.950 V versus the reference electrode of Ag/AgCl.At the applied voltage of 18 kV,the three analytes were completely separated within 18 min in 50 mmol/L borate buffer（pH10.00）with the injection time of 10 s.Good linear relationships were obtained for all the three analytes in the range of 2-100μmol/L.The detection limits for PHE,MR and IP were 0.8,0.8 and 1.0μmol/L,respectively.The proposed method was applied to the analysis of some injection drugs,and the results were satisfactory.