中文摘要：

猪的繁殖、呼吸的症候群病毒(PRRSV ) 在全世界作为猪的最重要的病原体之一被认出了。在 2006，中国的超过 10 个省经历了高发烧，使红的皮肤和高病态和死亡描绘的猪疾病的流行于家畜的爆发。从 2006 年 6 月到 2007 年 4 月，我们由 RT-PCR 在湖北省调查了一些临床的样品并且克隆几柱因， N， GP5 和 NSP2 基因，出现在这研究。这些基因的种系发生的分析表明高度病原的 PRRSV 变体， ZB，为在与在 2006 在中国从另外的省孤立的那些变体类似的湖北省的猪疾病的 2006 突现的爆发负责，并且属于 NA 类型 PRRSV。在 PRRSV 变体， N 和 GP5 砍有 prototypic ATCC VR-2332 和一些典型 NA 类型汉语的大约 90% 身份孤立，除了 2850bp NSP2 基因(仅仅与 ATCC VR-2332 分享 65% 身份) 。但是他们都砍多于并且有另外的高度病原的中国 PRRSV 的 97% 身份拉紧。另外，有广泛的氨基酸(一一) 在 GP5 蛋白质的变化和在 Nsp2 蛋白质的 2 删除什么时候与以前的 isolates 相比。大多数在中国在猪疾病的 2006 流行于家畜的爆发发现的变体是从在种系发生的距离的典型 NA 类型 PRRSV 的最远的变体，并且这些差异可能为在在这些变体和原来的中国 PRRSV 紧张之间观察的致病力的差别负责。

英文摘要：

Porcine reproductive and respiratory syndrome virus （PRRSV） has been recognized as one of the most important pathogens of pigs throughout the world. In 2006, more than 10 provinces of China have experienced an epizootic outbreak of pig diseases characterized by high fever, reddened skin and high morbidity and mortality. From June 2006 to April 2007, we have investigated some clinical samples in Hubei province by RT-PCR and cloned several major genes, N, GP5 and NSP2 gene, shown in this study. Phylogenetic analysis of these genes revealed that the highly pathogenic PRRSV variant, ZB, was responsible for 2006 emergent outbreak of pig disease in Hubei province similar with those variants isolated from other provinces in China in 2006, and belongs to the NA-type PRRSV. In the PRRSV variants, the N and GP5 shear about 90% identity with prototypic ATCC VR-2332 and some typical NA-type Chinese isolates, except the 2850bp NSP2 gene （only shares 65% identity with ATCC VR-2332）. But they all shear more than and 97% identity with other highly pathogenetic Chinese PRRSV strains. Additionally, there are extensive amino acid （aa） mutations in the GP5 protein and 2 deletions in the Nsp2 protein when compared with the previous isolates. Most of the variants found in 2006 epizootic outbreak of pig diseases in China were the farthest variants from the typical NA-type PRRSV in phylogenetic distance, and these diversities may be responsible for the differences in the pathogenicity observed between these variants and original Chinese PRRSV strains .