中文摘要：

目的评价中国汉族人群过氧化物酶体增殖物激活受体γ（PPARγ）基因多态性Pro12A la与2型糖尿病的相关性。方法以＂PPARγ＂、＂pparg＂、＂Pro12A la＂、＂type 2 d iabetes＂、＂Chinese＂、＂过氧化物酶增殖剂激活受体＂、＂2型糖尿病＂为检索词,全面检索2型糖尿病与Pro12A la相关的文献,用stata 11.0进行Meta分析,对研究数据的优势比（OR）值进行合并,并评价分析结果的可靠性和稳定性。结果 （1）检索到22篇,其中17篇符合纳入标准,包含了3927例2型糖尿患者和3364例正常对照,共7921名。纳入研究人群同质性较好,无显著发表偏倚。（2）次要等位基因A la12在正常人和2型糖尿病患者中的频率分别为4.8%与4.6%。在显性和加性遗传模式下,次要等位基因携带者相对于未携带者的OR值分别为0.95（95%C：I 0.80,1.12）和0.93（95%CI：0.79,1.09）。结论中国汉族人群PPARγ基因多态性Pro12A la与2型糖尿病无相关性。

英文摘要：

Objective To evaluate the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor γ（PPARγ） gene with type 2 diabetes（T2DM）in Chinese Han population.Methods The present investigation was carried out using the keywords ＂PPARγ＂,＂pparg＂,＂Pro12Ala＂,＂type 2 diabetes＂,and＂Chinese.The odds ratios（OR） for Ala12 used as the metric of choice were calculated in the dominant and additive model separately.The Meta-analysis was conducted by softeware STATA 11.0.Results（1） We identified 22 studies,of which 17 studies involving 3927 type 2 diabetes cases and 3364 controls fell into the inclusion criteria.The analysis indicated no significant inter-study heterogeneity and publication bias.（2） The frequencies of the minor allele Ala12 in type 2 diabetes and control groups were 4.8%and 4.6% respectively.（3） The combined overall OR of dominant and additive model calculated by fix-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism,were 0.95（95% CI：0.80,1.12） and 0.93（95% CI：0.79,1.09） respectively.Conclusion In this meta-analysis,the Pro12Ala gene variant（rs1801282） is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.