中文摘要：

目的制备介孔二氧化硅纳米粒,并研究其对黄酮类化合物（芹菜素、槲皮素、橙皮素）载药性能及药物释放的影响。方法制备负载黄酮类化合物的介孔二氧化硅纳米粒,扫描/透射电镜、傅里叶红外光谱仪、X射线衍射、氮气吸附-脱附解析对其进行表征,高效液相色谱仪测定纳米粒的载药量。结果所得纳米粒形状大小均一,平均粒径230-250 nm,比表面积为1045 cm^2/g,孔径2.8 nm。橙皮素、槲皮素和芹菜素的载药量分别为27%、23%和18%,40 min时的释放量分别为84%、80%和76%。结论介孔二氧化硅纳米粒可实现黄酮类化合物的高负载,并显著提高其在水溶液中的溶出度。

英文摘要：

AIM To prepare mesoporous silica nanoparticles and to study their impacts on flavonoid compounds＇（ apigenin,quercetin and hesperetin） drug loading and release. METHODS The characters of prepared mesoporous silica nanoparticles loaded with flavonoid compounds were determined by scan electron microscopy,transmission electron microscopy,Fourier transform infrared spectroscopy,X-ray diffraction and nitrogen adsorption-desorption analysis. The drug loadings of nanoparticles were then measured by high performance liquid chromatography（ HPLC）. RESULTS Found in a homogeneous shape,the obtained nanoparticles demonstrated their average particle sizes within the range of 230- 250 nm,with a specific surface area of 1 045 cm^2/ g and pore size of 2. 8 nm. In addition,for hesperetin,quercetin and apigenin,their releases at 40 min were 84%,80% and76% with the corresponding drug loadings of 27%,23% and 18%,respectively. CONCLUSION The mesoporous silica nanoparticles can help to achieve a high drug loading of flavonoid compounds,and significantly increase their dissolution rates in aqueous solutions.