中文摘要：

目的测定12种黄酮化合物的油水分配系数。方法采用经典摇瓶法与HPLC法测定油水分配系数,并进行比较。结果白杨素、芹菜素、木犀草素、山柰酚、桑色素、杨梅素、橙皮素、柚皮素、花旗松素、二氢杨梅素、刺芒柄花素、大豆黄素的Log P值分别为4.38、2.69、2.89、4.87、4.62、4.23、2.44、3.77、1.76、1.36、4.15、3.88。结论花旗松素与二氢杨梅素在体内能被较好地吸收,透过生物膜能力良好,而芹菜素、木犀草素和橙皮素亲脂性较强。黄酮化合物的油水分配系数与其结构有着密切关系。

英文摘要：

AIM To determine the oil-water partition coefficients of twelve flavonoids. METHODS The oil- water partition coefficients determined by classical shake-flask and HPLC methods were then compared. RE- SULTS The Log P values of chrysin, apigenin, luteolin, kaempferol, morin hydrate, myricetin, hesperetin, nar- ingenin, taxifolin, dihydromyricetin, formononetin and daidzein were 4. 38, 2.69, 2. 89, 4.87, 4.62, 4.23, 2.44, 3.77, 1.76, 1.36, 4. 15 and 3.88, respectively. CONCLUSION With good transmembrane capacities, taxifolin and dihydromyricetin can be well absorbed in vivo. And apigenin, luteolin and hesperetin show good li- pophilic properties. The oil-water partition coefficients of flavonoids depend greatly on their structures.