中文摘要：

前期的研究关于阿片类药物预处理的心肌保护效应，主要集中在心脏上的阿片受体在这种保护效应中的作用及信号机制。然而最新的研究已经发现通过中枢（侧脑室内，鞘内）注射吗啡预处理可以直接激活中枢阿片受体，同样可以模拟经典的缺血预处理（ischemia precondition，IPC）心肌保护效应，并且发现中枢神经系统3种阿片受体均参与介导了这种保护作用。这种保护作用的机制可能与痛觉的干预和神经递质的释放等效应有关。

英文摘要：

The majority of investigations about the cardioprotection induced by opioid preconditioning was focused on the role played by myocardial opioid receptors and the of signal mechanism. However, it has been found that directly activation of the opioid receptors in the central nervous system by intracerebroventricular/intrathecal morphine preconditioning also could mimic cardioprotective effects induced by ischemia preconditioning against ischemia-reperfusion injury, one had found also, the k-,δ- andμ-ORs of central nervous system were implicated in modulating the protective effect. This effect was probably induced by neurohumoral and analgesic substances.