肝细胞癌(HCC)是一种典型的富血管肿瘤,血管生成是HCC生长、侵袭、转移过程中必不可少的环节,许多促血管生长因子和血管生成抑制因子对HCC的血管生成起到调节作用。抗血管生成治疗是预防HCC复发转移的一个很有希望的治疗策略。
Hepatoeellular carcinoma (HCC) is one of the tumors that present typical neovascularization. Angiogenesis is of great importance for the development, invasion and metastasis of HCC. Angiogenesis in HCC is relied on the imbalance of downregulation of antiangiogenie factors and upregulation of proangiogenic factors. Therapies aiming at destruction of the tumor vasculature can achieve rapid regression of HCC. Antiangiogenesis is a kind of hopeful strategy for the prevention of relapse and metastasis of HCC.